I created a simple program with one click to open my excel file from local machine, I tried to find the related coding, unfortunately I couldn't get my excel file opens.
Imports Microsoft.Office.Interop Public Class Form1 Private Sub Button1_Click(sender As Object, e As EventArgs) Handles Button1.Click Dim xlApp As Microsoft.Office.Interop.Excel.Application Dim xlBook As Microsoft.Office.Interop.Excel.Workbook Dim xlSheet As Microsoft.Office.Interop.Excel.Worksheet xlApp = New Excel.Application xlBook = xlApp.Workbooks.Open("C:\Users\a-datan\Desktop\LyncAutomationConfig.xlsx") xlSheet = xlBook.Worksheets("sheet1") range = xlSheet.UsedRange For rCnt = 1 To range.Rows.Count For cCnt = 1 To range.Columns.Count Obj = CType(range.Cells(rCnt, cCnt), Excel.Range) ' Obj.value now contains the value in the cell.. Next Next End Sub