Visual Studio not detecting changes.

Just recently after I had made some changes to configurations of my solution and project Visual Studio 2012 stopped recognizing my changes and therefore does not build my changes when I select build.  I now have to select rebuild every time I want to build my project.  Even clicking start debugger does not detect that the project and solution is out of date.  After I make changes to a file and save it, if the project has already been build this is the total output from build:

Usually VS will iterate each project and output that it doesn't need to be built for this or that reason.  Any help is appreciated.