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Which is the best choice - X86 or Any CPU ? (VS 2010)

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Hi

I read in a blog:-

1. If the assembly is configured for Any CPU then it will run as x64 on a 64-bit machine and as x86 on a 32-bit machine.

2. If the assembly is configured for x86 then it will run as WOW64 on a 64-bit machine (i.e. a 32-bit process) and as x86 on a 32-bit machine.

My Questions are :-

1. If my application has to work on both 32 bit and 64 bit, which is the best choice ( X86 or Any CPU )?

2. If i change X86  to Any CPU or vice verse, will there be any issues?

Regards

Dominic


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