I have one computer which experiencing some weird issues when running VS 2012. My laptop is OK, But the desktop has problems. About every 5 - 10 times I initiate a debug session Javascript and CSS files which I have saved stay cached with the old code. Also, about every 20th time I will get a blank browser that doesn't even try to load the page. I have to exit VS and reload. It's Windows 8 Pro with VS 2012 SP2 installed.
I do not have the same problems with my Laptop which is the same configuration.