VS2012 -- Project settings not being saved

I have Visual Studio 2012, updated to Update 2.

Every time I open the application, it has the default settings as if the project was created new.

• The Debug build is selected, not the last build that was selected -- that is a custom build (SilverlightDebug) that we have defined.
• The client-side application is set as the StartUp Project, not the Web project.

Every time I open Visual Studio, I have to make these two changes.  

I have tried uninstalling and reinstalling Visual Studio 2012, but that did not fix the problem.